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Translational Medicine / 转化医学Clinical Cancer Proteomics, Drug Targets

Jacob Jaffe

PhD

🏢Broad Institute of MIT and Harvard🌐USA

Senior Director

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Key Contributions

👥Biography 个人简介

Jacob Jaffe at the Broad Institute has led clinical cancer proteomics efforts including CPTAC contributions and proteomics characterization of large cancer cell line collections. His work integrating proteomics with genomic data from cancer cell line pharmacology databases (CCLE) has connected protein expression patterns with drug sensitivity, providing a multi-omic framework for identifying cancer dependencies and predicting therapeutic response.

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🧪Research Fields 研究领域

clinical cancer proteomics
CPTAC Broad contribution
proteomics drug target validation
cancer cell line proteomics
quantitative proteomics

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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