Itay Tirosh

Itay Tirosh at Weizmann has been a pioneer in applying single-cell RNA sequencing to cancer, revealing the spectrum of transcriptional states within individual tumors. His work on melanoma and glioblastoma has demonstrated that cancer cells exist in continuous spectra of differentiation states that recapitulate developmental programs, with stem-like states often associated with drug resistance. These insights are reshaping understanding of tumor heterogeneity and therapeutic targeting.