Isabelle Ray-Coquard
伊莎贝尔·雷-科夸尔
MD, PhD
Professor of Medical Oncology; Head, Gynecological Oncology Unit肿瘤内科学教授；妇科肿瘤组主任
👥Biography 个人简介
Isabelle Ray-Coquard, MD, PhD is a Professor of Medical Oncology at Centre Léon Bérard and a leading expert on ovarian cancer biology and treatment. She led the PAOLA-1 trial, which established olaparib plus bevacizumab as first-line maintenance, significantly advancing PARP inhibitor and anti-angiogenic combination strategies in ovarian cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
PAOLA-1 Trial: Olaparib plus Bevacizumab First-Line Maintenance
Led the PAOLA-1/ENGOT-ov25 phase III trial demonstrating that adding olaparib to bevacizumab maintenance prolonged PFS in newly diagnosed advanced ovarian cancer, especially in HRD-positive patients.
HRD Biomarker Strategy in Ovarian Cancer
Championed the incorporation of HRD biomarker testing in clinical trial design and routine practice to stratify patients for PARP inhibitor combinations with bevacizumab.
Representative Works 代表性著作
Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer (PAOLA-1/ENGOT-ov25)
New England Journal of Medicine (2019)
Phase III trial establishing olaparib plus bevacizumab maintenance as a new standard of care for HRD-positive, newly diagnosed advanced ovarian cancer after platinum-taxane chemotherapy.
Olaparib plus bevacizumab first-line maintenance in ovarian cancer: final overall survival results from the PAOLA-1/ENGOT-ov25 trial
Annals of Oncology (2023)
Final OS analysis confirming long-term benefit of olaparib-bevacizumab maintenance in HRD-positive patients, with sustained separation of survival curves.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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