Ioana Popa
约阿娜·波帕
MD, PhD
Professor of Endocrinology and Molecular Oncology内分泌学与分子肿瘤学教授
👥Biography 个人简介
Ioana Popa at the University of Lille investigates the molecular pathology of adrenal cortical cancer, focusing on steroidogenic enzyme dysregulation, epigenetic reprogramming, and novel biomarkers for ACC diagnosis and prognosis. Her work links aberrant steroidogenesis to ACC aggressiveness and therapeutic resistance.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
ACC Steroidogenic Pathways
Characterized dysregulation of steroidogenic enzymes CYP11B1, CYP11B2, and 3β-HSD in adrenocortical carcinoma, revealing links between aberrant cortisol biosynthesis and tumor aggressiveness.
Epigenetic Biomarkers in ACC
Identified DNA methylation signatures and non-coding RNA profiles that distinguish benign from malignant adrenocortical tumors and predict recurrence after surgery.
Tumor Microenvironment in Adrenal Cancer
Investigated immunosuppressive tumor microenvironment features of ACC, including glucocorticoid-mediated immune evasion, providing rationale for immunotherapy combinations.
Representative Works 代表性著作
Steroidogenic Enzyme Expression and Prognosis in Adrenocortical Carcinoma
Journal of Clinical Endocrinology & Metabolism (2018)
Demonstrated that CYP11B1 expression correlates with secretory phenotype and adverse prognosis in a large ACC cohort.
DNA Methylation Profiling Identifies Distinct Molecular Subtypes of Adrenocortical Carcinoma
Endocrine-Related Cancer (2020)
Epigenome-wide analysis revealing methylation clusters with prognostic significance independent of established clinical variables.
Glucocorticoid-Mediated Immunosuppression in Adrenocortical Carcinoma: Implications for Immunotherapy
European Journal of Cancer (2022)
Mechanistic study demonstrating cortisol secretion suppresses anti-tumor immunity in ACC, supporting steroidogenesis inhibition as immunotherapy adjunct.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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