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Translational Medicine / 转化医学HER2 ADC, T-DM1 Development

Ian Krop

MD PhD

🏢Yale Cancer Center🌐USA

Professor

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Key Contributions

👥Biography 个人简介

Ian Krop at Yale contributed to the clinical development of T-DM1 (trastuzumab emtansine) — the first approved ADC for HER2-positive breast cancer — including the EMILIA and TH3RESA trials. His subsequent work on T-DXd compared to T-DM1 (DESTINY-Breast03 showing T-DXd superiority) and on mechanisms of HER2 ADC resistance has contributed to the evolution of HER2-directed ADC therapy in breast cancer.

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🧪Research Fields 研究领域

T-DM1 trastuzumab emtansine ado
EMILIA TH3RESA T-DM1 HER2
HER2 ADC mechanisms resistance
T-DXd T-DM1 comparison HER2
margetuximab HER2 breast cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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