Hudson Freeze

Hudson Freeze is a world authority on glycosylation disorders and has translated his deep understanding of glycan biosynthetic pathways into cancer biology, revealing how cancer cells rewire glycosylation machinery to support rapid proliferation and immune evasion. His work on congenital disorders of glycosylation identified essential glycosylation enzymes whose cancer-specific dependencies can be therapeutically exploited. He demonstrated that mannose supplementation can alter tumor glycosylation and impair cancer cell growth by disrupting glucose metabolism. His expertise in glycan biosynthetic pathways has identified new metabolic vulnerabilities in cancer.