Carolyn Hruban

Carolyn Hruban has developed methods to infer transcription factor binding and gene expression from cfDNA fragmentation patterns, expanding the information extractable from a single blood draw beyond cancer detection to tumor biology characterization. Her work on nucleosome footprinting from cfDNA fragments has enabled non-invasive inference of chromatin accessibility at gene promoters. Her contributions to fragmentomics data analysis pipelines have been essential for standardizing and scaling DELFI-based cancer detection across diverse clinical settings.