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Translational Medicine / 转化医学Oncolytic Virus, CNS Brain Tumor

Howard Fine

MD

🏢Weill Cornell Medicine🌐USA

Director, Brain Tumor Center

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👥Biography 个人简介

Howard Fine has investigated intratumoral oncolytic virus delivery for malignant brain tumors and contributed to early-phase trials of DNX-2401 (delta-24-RGD), a conditionally replicating adenovirus for GBM. His research has explored the immunological consequences of oncolytic virus therapy in the CNS tumor microenvironment and the challenge of overcoming the blood-brain barrier and immunosuppressive TME in GBM.

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🧪Research Fields 研究领域

oncolytic virus CNS tumors
GBM oncolytic therapy
DNX-2401 adenovirus GBM
brain tumor stem cells
glioma immunotherapy intratumoral

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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