Howard Chang

Howard Chang has made transformative contributions to understanding how long non-coding RNAs including XIST regulate chromatin states and gene expression in cancer, developing foundational technologies including ATAC-seq for chromatin accessibility profiling. His laboratory revealed that lncRNAs serve as molecular addresses to target chromatin-modifying complexes to specific genomic loci. He has identified cancer-specific lncRNA expression programs that drive tumor progression and therapy resistance. His technological innovations and biological insights have reshaped the fields of epigenomics and non-coding RNA cancer biology.