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Translational Medicine / 转化医学ADC Payload Innovation

Philip Howard

PhD

🏢AstraZeneca (formerly Spirogen/ADC Therapeutics)🌐United Kingdom

Vice President, Chemistry

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👥Biography 个人简介

Philip Howard is a medicinal chemist who pioneered pyrrolobenzodiazepine (PBD) dimer payloads for antibody-drug conjugates. His work on PBD warheads enabled the development of loncastuximab tesirine and other clinical-stage ADCs with enhanced potency against resistant tumors. He continues to innovate in linker-payload chemistry to improve ADC therapeutic windows.

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🧪Research Fields 研究领域

PBD payload chemistry
Pyrrolobenzodiazepine dimers
ADC linker-payload design
DNA-targeting payloads
Antibody-drug conjugate engineering

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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