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Translational Medicine / 转化医学Epigenetic Clock and Biological Aging

Steve Horvath

PhD, ScD

🏢Altos Labs🌐USA

Principal Investigator

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Key Contributions

👥Biography 个人简介

Steve Horvath developed the original pan-tissue epigenetic clock based on 353 CpG sites, which has become the gold standard for measuring biological age and its association with cancer risk. His subsequent development of GrimAge and skin-and-blood clocks has enabled precise quantification of aging acceleration in cancer patients and survivors. His work has established that epigenetic age acceleration predicts cancer incidence and mortality independent of chronological age.

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🧪Research Fields 研究领域

Epigenetic clock development
DNA methylation aging
Horvath clock
Pan-tissue age predictor
Biological age acceleration

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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