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Translational Medicine / 转化医学Capivasertib, AKT Inhibitors HR+ Breast

Hope Rugo

MD

🏢UCSF Helen Diller Family Comprehensive Cancer Center🌐USA

Professor of Medicine, Director Breast Oncology Clinical Trials

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👥Biography 个人简介

Hope Rugo at UCSF directs breast oncology clinical trials with expertise in novel targeted therapies for HR-positive disease. She was a key investigator in the CAPItello-291 trial of capivasertib plus fulvestrant, demonstrating improved outcomes in PIK3CA/AKT/PTEN-altered HR+ breast cancer. Her research encompasses CDK4/6 inhibitors, PI3K pathway agents, and antibody-drug conjugates for advanced breast cancer.

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🧪Research Fields 研究领域

capivasertib fulvestrant HR+
AKT inhibitor breast
PI3K pathway HR+ breast
HR+ clinical trials
triple-negative breast new agents

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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