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Translational Medicine / 转化医学DLBCL & Aggressive Lymphoma 2026

Hervé Tilly

埃尔韦·蒂利

MD, PhD

🏢Centre Henri Becquerel, Rouen(鲁昂亨利贝克勒尔癌症中心)🌐France

Head, Department of Hematology; Professor of Hematology, University of Rouen血液科主任;鲁昂大学血液学教授

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h-index
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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Hervé Tilly, MD, PhD is Head of Hematology at Centre Henri Becquerel, Rouen, and a leading figure in the LYSA cooperative group. He was coordinating investigator of the POLARIX trial and has led seminal LYSA studies on dose-dense R-CHOP and novel consolidation strategies, shaping frontline DLBCL treatment across Europe.

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🧪Research Fields 研究领域

DLBCL R-CHOP Polatuzumab POLARIX弥漫大B细胞淋巴瘤R-CHOP泊洛妥珠单抗POLARIX
Frontline DLBCL Clinical Trials弥漫大B细胞淋巴瘤一线临床试验
LYSA Lymphoma Cooperative GroupLYSA淋巴瘤研究协作组
DLBCL Dose-Dense R-CHOP弥漫大B细胞淋巴瘤剂量密集R-CHOP
Aggressive B Cell Lymphoma Consolidation侵袭性B细胞淋巴瘤巩固治疗

🎓Key Contributions 主要贡献

POLARIX Trial Coordination

Served as coordinating principal investigator of POLARIX, the global phase III trial that positioned pola-R-CHP as a new standard of care over R-CHOP for previously untreated intermediate/high-risk DLBCL.

LYSA Frontline DLBCL Trial Program

Led LYSA-sponsored trials evaluating dose-dense R-CHOP-14, consolidation maintenance, and treatment intensification strategies in young high-risk DLBCL patients.

Representative Works 代表性著作

[1]

Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma (POLARIX)

New England Journal of Medicine (2022)

Global phase III trial coordinated by Tilly demonstrating pola-R-CHP superiority over R-CHOP as first-line DLBCL treatment.

[2]

Diffuse large B-cell lymphoma: ESMO Clinical Practice Guidelines

Annals of Oncology (2015)

Comprehensive ESMO guidelines for DLBCL diagnosis, staging, and treatment written under Tilly's lead authorship.

🏆Awards & Recognition 奖项与荣誉

🏆LYSA (Lymphoma Study Association) Distinguished Investigator Award
🏆Société Française d'Hématologie Scientific Excellence Award
🏆Norman Cancer Centre Research Prize, Normandy Region

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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