Henning Willers
亨宁·威勒斯
MD
Associate Professor, Department of Radiation Oncology; Director, Experimental Radiation Oncology放射肿瘤学系副教授；实验放射肿瘤学主任
👥Biography 个人简介
Henning Willers directs Experimental Radiation Oncology at Massachusetts General Hospital and Harvard Medical School. His research focuses on DNA double-strand break repair mechanisms as determinants of radiation sensitivity and PARP inhibitors as radiosensitizers in lung cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
HR Repair as Radiation Sensitivity Biomarker
Identified homologous recombination repair capacity as a predictive biomarker for radiation sensitivity in NSCLC and breast cancer models.
PARP Inhibitor Radiosensitization
Demonstrated that PARP inhibitors synergize with ionizing radiation by impairing single-strand break repair causing lethal DSB accumulation.
Clinical DSB Repair Assays
Developed ex vivo gamma-H2AX-based assays to measure tumor DSB repair kinetics as functional radiosensitivity biomarkers.
Representative Works 代表性著作
Biomarkers and mechanisms of FANCD2 function in DNA damage responses and cancer
Environmental and Molecular Mutagenesis (2008)
Characterized Fanconi anemia pathway role in HR repair, linking germline defects to radiosensitivity.
Utility of DNA repair protein biomarkers in predicting clinical radiation resistance
Seminars in Radiation Oncology (2010)
Reviewed translational potential of DSB repair markers as radiosensitivity predictors in clinical tumors.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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