Silvia C. Formenti
西尔维亚·福尔门蒂
MD
Chairman and Professor, Department of Radiation Oncology放射肿瘤学系主任兼教授
👥Biography 个人简介
Silvia Formenti is Chair of Radiation Oncology at Weill Cornell Medicine and a global pioneer in combining radiation with immunotherapy. She led landmark trials demonstrating radiation-induced abscopal responses with checkpoint inhibitors, establishing radiation as an in situ tumor vaccine.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Radiation + Immunotherapy Clinical Trials
Led landmark trials combining radiotherapy with CTLA-4 and PD-1 blockade, demonstrating systemic abscopal tumor regression.
In Situ Tumor Vaccine Concept
Developed the concept of radiation as an in situ cancer vaccine, activating systemic anti-tumor immunity in metastatic patients.
Optimal Fractionation for Immunogenicity
Established optimal radiation dose-fractionation regimens that maximize immunogenic cell death and dendritic cell activation.
Representative Works 代表性著作
Radiotherapy induces responses of lung cancer to CTLA-4 blockade
Nature Medicine (2018)
Showed radiation converts immunologically cold tumors to respond to checkpoint inhibitors.
Systemic effects of local radiotherapy
The Lancet Oncology (2009)
Foundational review establishing immunological basis of abscopal effect in clinical practice.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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