Brian Marples
布莱恩·马普尔斯
PhD
Professor, Department of Radiation Oncology放射肿瘤学系教授
👥Biography 个人简介
Brian Marples is a leading radiobiologist at University of Rochester known for pioneering work on low-dose hypersensitivity and inverse dose-rate effects in cancer cells. His research has informed modern hypofractionated radiotherapy protocols and SBRT dose scheduling.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Low-Dose Hypersensitivity Research
Discovered and characterized low-dose hypersensitivity (HRS) and induced radioresistance (IRR) in human tumor cell lines, foundational to SBRT design.
Cell-Cycle Checkpoint Models
Developed mechanistic models explaining cell-cycle checkpoint activation in response to low-dose radiation exposure.
Fractionation Schedule Optimization
Advanced understanding of how fractionation schedules affect tumor control and normal tissue sparing in clinical radiotherapy.
Representative Works 代表性著作
Low-dose hyper-radiosensitivity: a consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells
Radiation Research (2004)
Established cellular basis for HRS/IRR, influencing SBRT dose-per-fraction design globally.
Hyper-radiosensitivity occurs for DNA double-strand break levels as low as one per cell
Radiation Research (2003)
Quantified threshold for HRS at single DSB level, fundamental to low-dose radiobiology.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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Weill Cornell Medicine / NewYork-Presbyterian Hospital
Paul M. Harari
University of Wisconsin School of Medicine and Public Health
Jeff Forman
Wayne State University / Karmanos Cancer Institute
Timothy N. Showalter
University of Virginia School of Medicine
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