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Translational Medicine / 转化医学Lobular Breast Cancer, CDH1, E-cadherin

Heini Muranen

PhD

🏢Weill Cornell Medicine🌐USA

Associate Professor

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Key Contributions

👥Biography 个人简介

Heini Muranen has contributed to understanding invasive lobular carcinoma (ILC) biology — the second most common breast cancer histology, characterized by CDH1/E-cadherin loss and distinct molecular biology from ductal cancer. ILC is particularly hormone receptor-positive, relatively chemoresistant, and has different patterns of metastasis compared to ductal cancer. Understanding the unique biology and therapeutic vulnerabilities of ILC is important for this underrepresented breast cancer subtype.

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🧪Research Fields 研究领域

lobular breast cancer biology
CDH1 E-cadherin lobular
ILC invasive lobular carcinoma
lobular breast cancer endocrine resistance
lobular breast cancer targeted therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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