Heather Hampel
希瑟·汉佩尔
MS, CGC
Associate Director, Division of Clinical Cancer Genetics临床癌症遗传学部副主任
👥Biography 个人简介
World-renowned genetic counselor and Lynch syndrome expert who pioneered universal mismatch repair (MMR) tumor testing for colorectal cancer. Her Ohio State studies established the evidence base for reflex MMR/MSI testing of all colorectal tumors at diagnosis.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Universal Lynch Syndrome Screening
Led seminal studies demonstrating that universal MMR immunohistochemistry testing of all newly diagnosed colorectal cancers identifies Lynch syndrome cases missed by family-history criteria, now standard of care.
Genetic Counseling Workforce
Trained generations of genetic counselors and developed scalable models for hereditary cancer genetic services, improving access to Lynch syndrome surveillance and risk reduction.
Representative Works 代表性著作
Feasibility of screening for Lynch syndrome among patients with colorectal cancer
Journal of Clinical Oncology (2008)
Demonstrated universal tumor MMR testing feasibility and identified Lynch syndrome prevalence of ~3% in unselected colorectal cancer patients.
PREMM5 model for predicting MLH1, MSH2, MSH6, PMS2, and EPCAM germline mutations
Journal of Clinical Oncology (2017)
Updated risk prediction model for Lynch syndrome incorporating all five MMR genes to guide referral for genetic testing.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
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