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Translational Medicine / 转化医学Oncogene Discovery, Cancer Biology Milestone

Harold Varmus

MD

🏢Weill Cornell Medicine🌐USA

Lewis Thomas University Professor

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Key Contributions

👥Biography 个人简介

Harold Varmus received the Nobel Prize for demonstrating that oncogenes originate from normal cellular genes (proto-oncogenes), fundamentally transforming understanding of cancer as a disease of gene regulation. His discovery that the Src oncogene has a cellular counterpart established the paradigm that cancer arises from alteration of normal growth control genes. As former NIH Director, he shaped cancer research policy for decades.

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🧪Research Fields 研究领域

proto-oncogene discovery
retroviral oncogenes
Src kinase
Nobel Prize medicine
cancer gene activation

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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