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Cell Therapy / 细胞治疗Next-Generation Cell Therapy

Hans Stauss

汉斯·施特劳斯

MD, PhD

🏢University College London(伦敦大学学院)🌐UK

Professor of Immunology and Director of Institute of Immunity & Transplantation免疫学教授兼免疫与移植研究所所长

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Internationally renowned immunologist specializing in TCR gene therapy targeting cancer-testis antigens. Developed high-affinity TCR gene transfer approaches for WT1, PRAME, and other shared tumor antigens, advancing multiple clinical trials in leukemia and solid tumors.

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🧪Research Fields 研究领域

TCR Gene TherapyTCR基因治疗
Cancer-Testis Antigen Targeting癌-睾丸抗原靶向
Adoptive T-Cell Immunotherapy过继性T细胞免疫治疗

🎓Key Contributions 主要贡献

TCR Gene Therapy for Cancer-Testis Antigens

Pioneered the use of high-affinity TCR gene transfer targeting WT1 and PRAME antigens in leukemia and solid tumors, establishing a platform for personalized and shared-antigen TCR therapy.

Representative Works 代表性著作

[1]

High-affinity WT1-specific TCR gene transfer: cancer-targeting T cells show effective anti-tumor activity against acute myeloid leukemia

Leukemia (2011)

Demonstrated that WT1-specific high-affinity TCR-engineered T cells mediate potent anti-leukemia activity in preclinical and early clinical models.

🏆Awards & Recognition 奖项与荣誉

🏆British Society for Immunology Immunology Medal
🏆Cancer Research UK Senior Fellowship

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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