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Translational Medicine / 转化医学Wnt Signaling, Intestinal Stem Cells, Organoids

Hans Clevers

MD

🏢Hubrecht Institute / Oncode Institute🌐Netherlands

Professor

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Key Papers
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Key Contributions

👥Biography 个人简介

Hans Clevers at the Hubrecht Institute discovered the Wnt pathway's central role in intestinal stem cell biology and colorectal cancer. He identified LGR5 as the intestinal stem cell marker, developed the organoid technology that has transformed cancer drug development and personalized medicine, and defined how aberrant Wnt/beta-catenin signaling drives colorectal carcinogenesis. His organoid platform is now used worldwide for cancer biology and drug testing.

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🧪Research Fields 研究领域

Wnt signaling
beta-catenin
intestinal stem cells
organoids cancer
colorectal cancer Wnt

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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