Guo-Hua Fong
冯国华
PhD
Professor, Center for Vascular Biology, Department of Cell Biology血管生物学中心、细胞生物学系教授
👥Biography 个人简介
Guo-Hua Fong is a vascular biologist renowned for delineating the distinct roles of VEGFR-1 and VEGFR-2 in developmental and tumor angiogenesis, and for discovering how PHD oxygen sensors regulate vascular formation in response to hypoxia. His work provides mechanistic insights into why VEGFR-targeted therapies have differential efficacy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
VEGFR-1 vs VEGFR-2 Functional Distinction
Generated VEGFR-1 and VEGFR-2 knockout mice demonstrating that these receptors have distinct and non-redundant roles in vascular development, providing mechanistic basis for receptor-selective anti-angiogenic strategies.
PHD Oxygen Sensors and Vascular Biology
Demonstrated that prolyl hydroxylase domain (PHD) proteins regulate HIF stability and VEGF expression in the vasculature, linking oxygen sensing directly to angiogenic control in tumors.
Representative Works 代表性著作
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
Nature (1995)
First genetic evidence that VEGFR-1 (Flt-1) is required for vascular assembly during embryogenesis, establishing its non-redundant role in angiogenesis.
Oxygen-sensitive PHDs regulate VEGF expression in angiogenesis
Journal of Clinical Investigation (2008)
Demonstrated PHD2 haploinsufficiency normalizes tumor vasculature by reducing HIF-VEGF signaling, offering a novel target for improving antiangiogenic therapy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Antoni Ribas
UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
关注 冯国华 的研究动态
Follow Guo-Hua Fong's research updates
留下邮箱，当我们发布与 Guo-Hua Fong（University of Connecticut Health Center）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment