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Translational Medicine / 转化医学FTO/ALKBH5 Erasers, Cancer Metabolism

Guifang Jia

PhD

🏢Peking University🌐China

Professor of Chemical Biology

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Key Papers
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Key Contributions

👥Biography 个人简介

Guifang Jia has made seminal contributions to understanding FTO and ALKBH5 as m6A eraser proteins in cancer. Her work revealed that ALKBH5 maintains glioblastoma stem cell tumorigenicity by demethylating FOXM1 mRNA, and that FTO promotes leukemogenesis through selective demethylation of oncogenic transcripts. These findings established m6A erasers as therapeutic targets across multiple cancer types.

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🧪Research Fields 研究领域

FTO demethylase cancer
ALKBH5 glioblastoma
m6A erasers
RNA demethylation
cancer metabolism epitranscriptomics

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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