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Translational Medicine / 转化医学Abiraterone, CYP17 Inhibition

Gregory Bhatt

MD

🏢University of California San Francisco🌐USA

Professor of Medicine

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Key Contributions

👥Biography 个人简介

Gregory Bhatt focuses on mechanisms of abiraterone resistance and the role of intratumoral steroid biosynthesis in prostate cancer. His research characterized how adrenal androgens and intracrine steroid production in tumor cells bypass abiraterone-mediated CYP17 blockade. He has evaluated glucocorticoid receptor overexpression as an alternative survival mechanism in abiraterone-resistant CRPC. His work has informed the development of next-generation CYP17 inhibitors designed to overcome abiraterone resistance mechanisms.

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🧪Research Fields 研究领域

abiraterone prostate
CYP17 inhibition
cortisol DHEA bypass
steroid biosynthesis cancer
resistant CRPC abiraterone

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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