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Translational Medicine / 转化医学Melanoma, BRAF Inhibitors, Tumor Biology

Grant McArthur

MD

🏢Peter MacCallum Cancer Centre🌐Australia

Executive Director, Victorian Comprehensive Cancer Centre

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Key Contributions

👥Biography 个人简介

Grant McArthur at Peter Mac led and contributed to the BRIM-3 and BRIM-7 trials that established vemurafenib alone and in combination with cobimetinib as standards in BRAF V600-mutated melanoma. His research on mechanisms of acquired BRAF inhibitor resistance and strategies to overcome it — including re-challenge and combination approaches — has advanced understanding and management of resistance in melanoma.

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🧪Research Fields 研究领域

melanoma
BRAF inhibitors
vemurafenib
BRIM-3 trial
melanoma resistance mechanisms

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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