Giorgio Trinchieri

Giorgio Trinchieri is a distinguished cancer immunologist who discovered interleukin-12 and has more recently investigated the role of the gut microbiome in cancer immunotherapy responses. His laboratory has characterized how specific microbiome species activate innate immune pathways including TLR signaling to modulate anti-tumor immunity and immunotherapy efficacy. He has contributed to mechanistic understanding of how the microbiome fine-tunes immune responses at the systemic level. His work integrates decades of cytokine biology expertise with emerging microbiome science to advance cancer immunotherapy.