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Translational Medicine / 转化医学DLBCL & Aggressive Lymphoma 2026

Gilles Salles

吉尔·萨莱斯

MD, PhD

🏢Memorial Sloan Kettering Cancer Center(纪念斯隆凯特琳癌症中心)🌐USA

Chief, Lymphoma Service; Attending Physician淋巴瘤科主任;主治医师

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Gilles Salles, MD, PhD is Chief of the Lymphoma Service at Memorial Sloan Kettering Cancer Center. Previously at Hospices Civils de Lyon, he is internationally recognized for pioneering clinical development of bispecific antibodies—including mosunetuzumab, glofitamab, and loncastuximab—in relapsed/refractory B cell lymphomas.

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🧪Research Fields 研究领域

DLBCL Mosunetuzumab Bispecific弥漫大B细胞淋巴瘤莫苏妥珠单抗双特异性抗体
Loncastuximab TesirineLoncastuximab Tesirine
Glofitamab Bispecific AntibodyGlofitamab双特异性抗体
Follicular Lymphoma Immunotherapy滤泡性淋巴瘤免疫治疗
Novel Antibody-Based Therapies新型抗体靶向治疗

🎓Key Contributions 主要贡献

Bispecific Antibody Development in DLBCL

Led pivotal trials of CD20xCD3 bispecific antibodies (mosunetuzumab, glofitamab) and CD19-targeted ADC loncastuximab, establishing new treatment options for heavily pre-treated DLBCL and follicular lymphoma.

International Lymphoma Research Leadership

Serves on ESMO, EHA, and ASH lymphoma committees; led European Mantle Cell Lymphoma Network and Global Lymphoma Alliance initiatives to harmonize treatment guidelines.

Representative Works 代表性著作

[1]

Mosunetuzumab in Relapsed or Refractory Follicular Lymphoma

New England Journal of Medicine (2022)

Pivotal study demonstrating durable complete responses with mosunetuzumab, a CD20xCD3 T cell-engaging bispecific antibody, in follicular lymphoma.

[2]

Glofitamab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma

New England Journal of Medicine (2023)

Phase II trial reporting high complete response rates with glofitamab in multiply relapsed DLBCL, leading to accelerated FDA approval.

🏆Awards & Recognition 奖项与荣誉

🏆EHA Lifetime Achievement Award in Lymphoma
🏆French National Cancer Institute (INCa) Excellence Award
🏆ASH Plenary Session Abstract Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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