George Sgouros

George Sgouros is the world's leading expert on dosimetry for radioligand therapy, developing patient-specific dose calculation methods that enable personalized treatment planning based on individual tumor uptake and normal organ radiation exposure. His dosimetric models for Lu-177 and Ac-225 radioligand therapies have established the dose-response relationships that guide optimal treatment dosing and predict toxicity to kidneys, bone marrow, and salivary glands. He has advanced alpha-particle dosimetry methods addressing the unique microdosimetric challenges of short-range high-LET alpha emitters. His work on dosimetry-guided treatment intensification aims to safely maximize tumor-absorbed doses, improving radioligand therapy efficacy.