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Translational Medicine / 转化医学Sarcoma, GIST, Imatinib

George Demetri

MD

🏢Dana-Farber Cancer Institute🌐USA

Director, Ludwig Center at Harvard

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Key Contributions

👥Biography 个人简介

George Demetri at Dana-Farber co-led the pivotal trials establishing imatinib as standard of care for gastrointestinal stromal tumors (GIST), one of the first and most successful examples of molecularly targeted therapy in oncology. His foundational work on KIT and PDGFRA oncogenic signaling in GIST and his leadership of international sarcoma cooperative group trials have transformed management of this rare but paradigmatic cancer.

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🧪Research Fields 研究领域

GIST
imatinib
KIT inhibition
sarcoma biology
sarcoma clinical trials

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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