George A. Calin
乔治·卡林
MD, PhD
Professor and Deputy Division Head for Research, Translational Molecular Pathology; Marnie Rose Foundation Distinguished Professor转化分子病理学系研究副主任兼教授；玛妮·罗斯基金会杰出教授
👥Biography 个人简介
Discoverer of the first cancer-associated microRNA deletion, fundamentally changing understanding of cancer biology. His pioneering work established circulating microRNAs as stable, cancer-specific biomarkers in blood, creating the foundation for non-coding RNA-based liquid biopsy and cancer diagnostics.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
MicroRNA Discovery in Cancer
Identified miR-15a/16-1 deletion in CLL, the first evidence linking microRNA loss to cancer, establishing non-coding RNAs as oncogenes and tumor suppressors and opening an entirely new field.
Circulating ncRNA Liquid Biopsy
Demonstrated that circulating microRNAs and other non-coding RNAs are stable in plasma and serum, serving as minimally invasive diagnostic and prognostic biomarkers across multiple cancer types.
Representative Works 代表性著作
Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
Proceedings of the National Academy of Sciences (2002)
Seminal discovery linking miR-15a/16-1 deletion to CLL, the first paper connecting microRNA to human cancer.
Circulating microRNAs as stable blood-based markers for cancer detection
Proceedings of the National Academy of Sciences (2008)
Established that microRNAs are stable in serum and plasma and can serve as blood-based biomarkers for cancer detection.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Antoni Ribas
UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
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