Georg Lenz
格奥尔格·伦茨
MD
Director, Department of Medicine A (Hematology/Oncology); Professor of MedicineA科（血液/肿瘤学）主任；医学教授
👥Biography 个人简介
Georg Lenz, MD is Director of Hematology and Oncology at University Hospital Münster. A pioneer in DLBCL molecular biology, his work elucidating GCB vs ABC cell-of-origin subtypes and the chronic active BCR/NF-κB signaling mechanism in ABC-DLBCL has been fundamental to subtype-specific therapeutic targeting.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
DLBCL Molecular Subtype Biology
Characterized chronic active B cell receptor signaling as the key oncogenic driver of ABC-DLBCL and identified MYD88/CD79B co-mutations defining a targetable subset responsive to BTK inhibition.
Targeted Therapy Rationale in ABC-DLBCL
Provided preclinical and translational evidence supporting ibrutinib and other BCR pathway inhibitors in MYD88L265P-mutated ABC-DLBCL, informing multiple international clinical trials.
Representative Works 代表性著作
Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
Science (2008)
Landmark study identifying activating CARD11 mutations driving constitutive NF-κB signaling in ABC-DLBCL, establishing a key oncogenic mechanism.
Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
Proceedings of the National Academy of Sciences (2008)
Comprehensive genomic analysis distinguishing GCB and ABC DLBCL by mutation spectra, defining distinct oncogenic pathways and therapeutic targets.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Antoni Ribas
UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
关注 格奥尔格·伦茨 的研究动态
Follow Georg Lenz's research updates
留下邮箱，当我们发布与 Georg Lenz（University Hospital Münster）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment