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Translational Medicine / 转化医学DLBCL Biology, ABC DLBCL NF-kB Signaling

Georg Lenz

MD

🏢University Hospital Munster🌐Germany

Professor and Director, Department of Oncology and Hematology

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👥Biography 个人简介

Georg Lenz is a translational hematologist who developed the LymphGen genetic classification of DLBCL, which stratifies DLBCL into genetically distinct subgroups with different biology and therapeutic vulnerabilities. He characterized BCR-NF-kB addiction in ABC DLBCL and the rationale for BTK inhibitors in ABC-subtype patients. His work on double-hit and double-expressor lymphoma has contributed to understanding high-grade B cell lymphoma biology. His comprehensive molecular classification tools are increasingly used to guide clinical trial enrollment and treatment selection in DLBCL.

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🧪Research Fields 研究领域

ABC DLBCL NF-kB BCR signaling
ibrutinib BTK inhibitor DLBCL ABC subtype
DLBCL genetic classification LymphGen
DLBCL BCL2 BCL6 MYC double hit
DLBCL high-grade B cell lymphoma biology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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