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Translational Medicine / 转化医学MHC Neoantigen Immunosurveillance, Glioma

Gavin Dunn

MD, PhD

🏢Washington University in St. Louis🌐USA

Associate Professor of Neurosurgery and Immunology

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👥Biography 个人简介

Gavin Dunn has advanced understanding of how MHC-restricted neoantigen presentation drives immunosurveillance in brain tumors. His work on glioma immunoediting demonstrated that brain tumors selectively lose immunogenic neoantigens under T cell pressure despite the presumed immune privilege of the CNS. He has developed approaches to enhance neoantigen presentation in immunologically cold brain tumors through combination therapy.

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🧪Research Fields 研究领域

MHC neoantigen presentation
glioma immunosurveillance
cancer immunoediting brain
neoantigen-specific T cells
brain tumor immunology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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