Frédéric Castinetti

Frédéric Castinetti, MD, PhD is Professor of Endocrinology and Head of the Department of Endocrinology at Aix-Marseille University and La Conception Hospital in Marseille, France. He is an internationally recognized expert in hereditary endocrine cancer syndromes, with a particular focus on Multiple Endocrine Neoplasia type 2 (MEN2), medullary thyroid cancer (MTC), and pituitary tumor genetics. His research integrates molecular genetics, clinical endocrinology, and surgical oncology to optimize outcomes for patients with hereditary endocrine neoplasias. Professor Castinetti has made seminal contributions to the understanding of genotype–phenotype correlations in MEN2, providing critical evidence for timing recommendations on prophylactic thyroidectomy in RET mutation carriers. He led studies on outcomes of MTC in MEN2A and MEN2B patients treated at reference centers in France, contributing to European consensus guidelines. His research on rare pituitary tumors, including pituitary carcinomas and aggressive adenomas, complements his MEN work and addresses the full spectrum of endocrine neoplasia syndromes. He chairs the French Society of Endocrinology working group on hereditary endocrine tumors, contributes to the European Reference Network on Rare Endocrine Conditions (Endo-ERN), and has co-authored over 200 peer-reviewed publications. He is a frequent invited speaker at the European Congress of Endocrinology and American Thyroid Association meetings.