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Translational Medicine / 转化医学RAS Biology, KRAS Inhibitors

Frank McCormick

MD

🏢UCSF Helen Diller Family Comprehensive Cancer Center🌐USA

Distinguished Professor Emeritus

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Key Contributions

👥Biography 个人简介

Frank McCormick has spent decades deciphering RAS signaling and working to develop RAS-targeted cancer therapies. His discovery of the GAP mechanism for RAS deactivation and his foundational work on RAS effector pathways have underpinned decades of KRAS drug discovery effort. He founded a series of companies targeting RAS and has been instrumental in the development of KRAS G12C inhibitors.

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🧪Research Fields 研究领域

RAS signaling
KRAS
GAP proteins
NF1
RAS drug targeting

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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