Francesco Bertolini
弗朗切斯科·贝尔托利尼
MD, PhD
Head, Laboratory of Hematology-Oncology and Vascular Biology血液肿瘤学与血管生物学实验室主任
👥Biography 个人简介
Francesco Bertolini pioneered the use of circulating endothelial cells (CECs) as non-invasive biomarkers of tumor angiogenesis and antiangiogenic therapy response. He also played a foundational role in establishing metronomic chemotherapy as an antiangiogenic strategy, changing how low-dose continuous chemotherapy is conceptualized.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Circulating Endothelial Cells as Angiogenesis Biomarkers
Developed methods to quantify and characterize CECs from peripheral blood, establishing them as pharmacodynamic markers of antiangiogenic therapy and tumor vascularity in clinical trials.
Metronomic Chemotherapy and Angiogenesis
Demonstrated that low-dose metronomic chemotherapy suppresses tumor angiogenesis via endothelial cell targeting and Treg depletion, providing mechanistic rationale for this cost-effective antiangiogenic strategy.
Representative Works 代表性著作
Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells
Cancer Research (2003)
Landmark study showing metronomic and maximum-tolerable-dose chemotherapy differ fundamentally in their effects on circulating endothelial progenitors and tumor angiogenesis.
Circulating endothelial cells as a novel marker of angiogenesis
Journal of Clinical Oncology (2006)
Established clinical validation of circulating endothelial cells as a surrogate marker of angiogenic activity and bevacizumab pharmacodynamics in cancer patients.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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留下邮箱，当我们发布与 Francesco Bertolini（IEO – Istituto Europeo di Oncologia (European Institute of Oncology)）相关的新研究或访谈时，我们会通知你。
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