Fortunato Ciardiello
福图纳托·恰尔迪耶洛
MD, PhD
Professor of Medical Oncology & Director, Division of Medical Oncology医学肿瘤学教授兼医学肿瘤科主任
👥Biography 个人简介
Prof. Fortunato Ciardiello is a pioneer in EGFR-targeted therapy for colorectal cancer. He led the CAVE-CRC trial demonstrating the efficacy of cetuximab rechallenge guided by liquid biopsy, revolutionizing treatment strategies for RAS/BRAF wild-type metastatic CRC.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
EGFR Rechallenge Strategy
Led the CAVE-CRC trial demonstrating that liquid biopsy-guided cetuximab rechallenge with avelumab is effective in RAS/BRAF wild-type metastatic CRC after prior anti-EGFR therapy, establishing rechallenge as a validated treatment strategy.
Anti-EGFR Resistance Mechanisms
Defined molecular mechanisms of acquired resistance to EGFR inhibitors in CRC, including clonal evolution of RAS/BRAF mutations detectable in plasma ctDNA, enabling rational rechallenge sequencing strategies.
Representative Works 代表性著作
Avelumab plus cetuximab as a rechallenge strategy for RAS/BRAF wild-type metastatic CRC (CAVE-CRC)
ESMO Open (2021)
Phase II CAVE-CRC trial supporting liquid biopsy-guided anti-EGFR rechallenge in RAS/BRAF wild-type mCRC.
Epidermal growth factor receptor (EGFR) inhibitors as anti-EGFR therapy in colorectal cancer
Annals of Oncology (2020)
Comprehensive review of EGFR inhibitor mechanisms, predictive biomarkers, and emerging resistance patterns in mCRC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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