Florent Mouliere
弗洛朗·穆利耶尔
PhD
Associate Professor of Liquid Biopsy and Translational Oncology液体活检与转化肿瘤学副教授
👥Biography 个人简介
Expert in cfDNA fragment size biology and its application for cancer detection. Discovered that short cfDNA fragments are enriched for tumor-derived sequences, enhancing ctDNA detection sensitivity. His work on glioma and brain tumor liquid biopsy has expanded the clinical scope of cfDNA diagnostics.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Short cfDNA Fragment Enrichment
Demonstrated that size-selecting for short cfDNA fragments (below 150 bp) enriches tumor-derived DNA, substantially improving ctDNA detection sensitivity in early-stage cancers.
Brain Tumor Liquid Biopsy
Pioneered use of cfDNA fragmentation and methylation for non-invasive detection and monitoring of gliomas and brain metastases, where ctDNA levels are typically extremely low.
Representative Works 代表性著作
Improved detection of circulating tumor DNA by optimized extraction and sizing
Oncotarget (2016)
Showed size-selection of short cfDNA fragments substantially improves ctDNA detection sensitivity across multiple cancer types.
Liquid biopsy-based detection of residual disease after radiotherapy for brain metastases
Nature Communications (2022)
Demonstrated cfDNA-based MRD detection in brain tumors using fragmentation and methylation signals after radiotherapy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Naiyer A. Rizvi
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