Paul Fisch

Paul Fisch characterized the role of gamma-delta T cells in tumor immune microenvironments across diverse cancer types through comprehensive immunohistochemical and molecular analyses, demonstrating that high gamma-delta T cell infiltration correlates with improved prognosis in colorectal, breast, and ovarian cancers. His molecular pathology work established diagnostic criteria for gamma-delta T cell lymphomas and leukemias using TCR gene rearrangement analysis, distinguishing these rare malignancies from alpha-beta T cell neoplasms. He has mapped the spatial distribution of gamma-delta T cells within tumor architecture to understand their functional interactions with other immune populations.