Filippo Rossi Fanelli
菲利波·罗西·法内利
MD
Professor Emeritus of Internal Medicine and Clinical Nutrition内科学与临床营养学荣誉教授
👥Biography 个人简介
Filippo Rossi Fanelli is a foundational figure in Italian and European clinical nutrition, whose research illuminated cancer-specific alterations in protein and amino acid metabolism underlying malnutrition and cachexia. He helped establish Sapienza Rome as a global center for clinical nutrition research.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Protein and Amino Acid Metabolism in Cancer
Characterized whole-body protein turnover and amino acid utilization abnormalities in cancer patients, demonstrating accelerated protein catabolism as a hallmark of cancer malnutrition independent of food intake.
Cancer Anorexia Mechanisms
Investigated central and peripheral mechanisms of cancer-related anorexia, including hypothalamic cytokine signaling and serotonin pathways, providing mechanistic targets for appetite restoration.
Nutritional Support Strategies in Advanced Cancer
Developed and evaluated nutritional support regimens including branched-chain amino acid supplementation and immunonutrition in cancer patients, contributing to evidence-based clinical nutrition protocols.
Representative Works 代表性著作
Altered amino acid and glucose metabolism in patients with cancer anorexia
Cancer Research (1991)
Classic metabolic study demonstrating fundamental differences in amino acid and glucose utilization in cancer anorexia versus starvation, establishing the distinct metabolic basis of cancer malnutrition.
Cancer anorexia: new pathogenic and therapeutic insights
Nutrition (1998)
Comprehensive review integrating cytokine, neuropeptide, and metabolic mechanisms of cancer anorexia, guiding pharmacological intervention strategies.
Branched-chain amino acids supplementation and cancer cachexia: the evidence from clinical trials
Clinical Nutrition (2006)
Systematic review evaluating BCAA supplementation trials in cancer cachexia, synthesizing efficacy data to inform practical nutritional supplementation recommendations.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
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