Filippo Pietrantonio
菲利波·彼得兰托尼奥
MD
Head, Gastrointestinal Medical Oncology Unit胃肠肿瘤内科学科主任
👥Biography 个人简介
Dr. Filippo Pietrantonio is a leading expert in molecular biomarker-driven treatment of metastatic CRC. He has pioneered liquid biopsy approaches for EGFR rechallenge selection and HER2-targeted strategies, publishing extensively on precision oncology in CRC.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Liquid Biopsy for EGFR Rechallenge
Established ctDNA-based RAS/BRAF status monitoring as a predictive biomarker for anti-EGFR rechallenge in metastatic CRC, enabling patient selection and improving rechallenge response rates in prospective trials.
HER2 Targeting in CRC
Led translational and clinical studies on HER2 amplification in CRC, defining optimal testing methodology, co-alterations affecting response, and resistance mechanisms to anti-HER2 combinations such as trastuzumab plus lapatinib.
Representative Works 代表性著作
Heterogeneity of acquired resistance to anti-EGFR monoclonal antibodies in patients with metastatic CRC
Nature Medicine (2021)
Defined ctDNA-based resistance mechanisms driving anti-EGFR treatment failure and rechallenge response prediction.
HER2 in colorectal cancer: ready for prime time?
Annals of Oncology (2022)
Comprehensive review of HER2 amplification prevalence, testing approaches, and clinical trial outcomes in CRC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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