Filip Janku
菲利普·扬库
MD, PhD
Professor, Investigational Cancer Therapeutics研究性癌症治疗学教授
👥Biography 个人简介
Filip Janku is a leading early-phase trial investigator specializing in BRAF and RAS pathway-targeted therapies. He has conducted pivotal first-in-human trials of BRAF V600E inhibitors and combination regimens, and led clinical development of novel agents in colorectal and other BRAF-mutated cancers.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
BRAF-Mutated Colorectal Cancer Trials
Led early and late-phase trials of BRAF/MEK/EGFR triple combination regimens in BRAF V600E-mutated colorectal cancer, contributing to regulatory approval of encorafenib plus cetuximab.
Novel RAS Pathway Agent Development
Investigated first-in-human trials of direct KRAS G12C and pan-RAS inhibitors, defining safety profiles and early efficacy signals in heavily pre-treated solid tumor populations.
Autophagy Inhibitor Combinations
Pioneered clinical investigation of autophagy inhibition (hydroxychloroquine) combined with targeted agents, exploring resistance mechanisms in RAS/RAF-mutated cancers.
Representative Works 代表性著作
Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations
New England Journal of Medicine (2014)
First large basket trial demonstrating BRAF V600E inhibitor activity across multiple non-melanoma tumor types.
Phase I/II Study of Binimetinib, Encorafenib, and Cetuximab in BRAF V600E-Mutant Colorectal Cancer
Journal of Clinical Oncology (2020)
Established efficacy and safety of triplet targeted therapy in BRAF-mutated CRC, informing standard combination regimens.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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Institute of Cancer Research / Royal Marsden Hospital
Timothy Yap
The University of Texas MD Anderson Cancer Center
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Alison Schram
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