Felix Y. Feng
冯乙
MD
Professor of Radiation Oncology, Urology, and Medicine; Co-Leader, Prostate Cancer Program放射肿瘤学、泌尿外科及内科教授；前列腺癌项目联合负责人
👥Biography 个人简介
Prof. Felix Feng is a leading prostate cancer translational researcher at UCSF specializing in radiation genomics and AR splice variant biology. He has defined genomic biomarkers predicting response to radiotherapy intensification and characterized AR-V7 as a key resistance mechanism in mCRPC.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
AR Splice Variant Biology and Resistance
Characterized androgen receptor splice variant AR-V7 biology in mCRPC, demonstrating its role in resistance to enzalutamide and abiraterone, and developing clinical assays for AR-V7 detection to guide therapy selection.
Radiation Genomics in Prostate Cancer
Developed genomic classifiers predicting benefit from radiation intensification and ADT in localized prostate cancer, enabling precision radiotherapy approaches and reducing overtreatment.
Representative Works 代表性著作
Androgen Receptor Splice Variant 7 and Efficacy of Taxane Chemotherapy in Patients with Metastatic Castration-Resistant Prostate Cancer
JAMA Oncology (2015)
Showed that AR-V7 positive mCRPC patients have preferential benefit from taxane chemotherapy over hormonal agents.
Genomic Classifiers Predict Metastasis and Mortality in Patients Treated with Salvage Radiation Therapy for Biochemical Recurrence
Journal of Clinical Oncology (2016)
Validated Decipher genomic classifier for risk stratification guiding adjuvant therapy decisions after prostatectomy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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