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Translational Medicine / 转化医学ALT-Associated PML Bodies, DNA Repair

Eros Lazzerini Denchi

PhD

🏢National Cancer Institute / NIH🌐USA

Associate Professor

30
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Key Papers
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Key Contributions

👥Biography 个人简介

Eros Lazzerini Denchi has elucidated the molecular mechanisms of ALT-associated PML bodies (APBs) and their role in telomere maintenance. His work revealed how DNA damage repair proteins are recruited to APBs to mediate break-induced replication at telomeres in ALT cancers. He has identified key regulators of the ALT pathway that represent therapeutic vulnerabilities in ATRX/DAXX-mutant cancers.

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🧪Research Fields 研究领域

ALT PML bodies
telomere DNA repair
NBS1 telomere recruitment
break-induced replication
telomere recombination

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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