Erik Sahai

Erik Sahai is a leading TME researcher at the Francis Crick Institute whose work has illuminated how physical and molecular interactions between cancer cells and stromal fibroblasts drive tumor progression. His intravital imaging studies revealed how cancer cells harness fibroblast-produced matrix remodeling for invasion and metastasis. He identified how tumor mechanical forces and ECM stiffness feedback into CAF activation programs. His systems-level analyses of the tumor microenvironment have generated actionable insights for stromal intervention.