Eric L. Smith
埃里克·史密斯
MD, PhD
Attending Physician & Associate Member, Myeloma Service骨髓瘤科主治医师暨副研究员
👥Biography 个人简介
Eric Smith at MSK is a leading developer of bispecific antibodies for myeloma. He led translational and clinical research on teclistamab (BCMA × CD3), the first bispecific antibody approved for myeloma, and continues advancing next-generation T-cell redirecting strategies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Teclistamab Development
Played a foundational role in the preclinical and clinical development of teclistamab (JNJ-64007957), the first BCMA × CD3 bispecific antibody approved by FDA (2022) for relapsed/refractory myeloma.
Bispecific Antibody Mechanisms and Resistance
Conducted mechanistic studies elucidating how BCMA × CD3 bispecifics engage T cells in the myeloma microenvironment and defined resistance mechanisms including BCMA downregulation and T-cell exhaustion.
Novel Target Discovery for Myeloma Immunotherapy
Identified and validated FcRH5 (FCRL5) as a myeloma surface target, enabling development of cevostamab, a FcRH5 × CD3 bispecific demonstrating activity in BCMA-exposed patients.
Representative Works 代表性著作
Teclistamab in Relapsed or Refractory Multiple Myeloma (MajesTEC-1)
New England Journal of Medicine (2022)
Phase I/II trial demonstrating 63% ORR with teclistamab, leading to FDA approval as the first BCMA × CD3 bispecific antibody.
FcRH5/CD3 Bispecific Antibody Cevostamab in Myeloma
Cancer Cell (2021)
Preclinical and early clinical data establishing FcRH5 as a clinically actionable target for bispecific-mediated T-cell redirection in myeloma.
BCMA Downregulation and Resistance to Bispecific Antibodies in Myeloma
Blood (2023)
Mechanistic study characterizing BCMA loss as a primary resistance mechanism and evaluating combinatorial strategies to overcome it.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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University of Pennsylvania
Michel Sadelain
Memorial Sloan Kettering Cancer Center
Crystal L. Mackall
Stanford University
Katy Rezvani
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