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Translational Medicine / 转化医学PIK3CA, HR+ Breast Cancer Resistance

Eric Bhatt

MD PhD

🏢Johns Hopkins Sidney Kimmel Cancer Center🌐USA

Assistant Professor of Oncology

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Key Contributions

👥Biography 个人简介

Eric Bhatt studies PI3K pathway activation as a driver of endocrine and CDK4/6 inhibitor resistance in hormone receptor-positive breast cancer. His research characterized how PIK3CA mutations cooperate with ESR1 mutations to confer multi-drug resistance. He has evaluated alpelisib and inavolisib combinations with endocrine therapy in PIK3CA-mutant breast cancer. His translational work identifies biomarkers that predict benefit from PI3K pathway inhibition in this common cancer subtype.

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🧪Research Fields 研究领域

PIK3CA alpelisib
PI3K HR+ breast cancer
AKT inhibitors breast
CDK4/6 PI3K combination
PTEN loss breast

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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