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Translational Medicine / 转化医学Cancer DNA Damage and Replication Stress

Stephen Elledge

PhD

🏢Harvard Medical School and Brigham and Women's Hospital🌐USA

Gregor Mendel Professor of Genetics and Medicine; Howard Hughes Medical Institute Investigator

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👥Biography 个人简介

Stephen Elledge discovered the DNA damage checkpoint system and has defined how cells sense and respond to DNA damage through CHK1, CHK2, and related kinases. His work underpins the development of cancer therapies targeting the DNA damage response. He is a Breakthrough Prize laureate and one of the field's founders.

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🧪Research Fields 研究领域

DNA damage response
checkpoint kinases
CHK1 CHK2
cancer synthetic lethality
replication stress

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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