Elena Sotillo
埃琳娜·索蒂略
PhD
Research Scientist, Division of Hematology血液学部门研究科学家
👥Biography 个人简介
Expert in mechanisms of CAR-T therapy resistance, particularly antigen escape through CD19 loss. Pioneered CRISPR-based combinatorial antigen targeting strategies to prevent tumor escape and improve durable remission in B-cell malignancies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CAR-T Resistance and Antigen Escape
Identified key molecular mechanisms by which leukemia cells downregulate CD19 to escape CAR-T surveillance, and developed combinatorial CRISPR targeting to circumvent resistance.
Representative Works 代表性著作
Convergence of acquired mutations and alternative splicing of CD19 enables resistance to CART-19 immunotherapy
Cancer Discovery (2015)
Defined the molecular basis of CD19 loss and alternative splicing as major drivers of CAR-T therapy failure in B-ALL.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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