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Translational Medicine / 转化医学Hippo/YAP Pathway, Pathway Discovery

Duojia Pan

PhD

🏢University of Texas Southwestern Medical Center🌐USA

Professor of Physiology

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Key Contributions

👥Biography 个人简介

Duojia Pan discovered key components of the Hippo signaling pathway through landmark Drosophila genetic screens. His research established the core Hippo kinase cascade from MST1/2 to LATS1/2 to YAP/TAZ and defined its fundamental role in organ size control. His work in Drosophila provided the conceptual framework for understanding Hippo pathway dysregulation in human cancers. He continues to investigate Hippo pathway mechanisms and their therapeutic relevance across multiple cancer types.

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🧪Research Fields 研究领域

Hippo signaling pathway
YAP/TAZ transcription
organ size control
tumor suppressor MST1/2
LATS1/2 kinases

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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